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Source: http://www.msnbc.msn.com/id/21134540/vp/46202265#46202265
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CANBERRA, Australia ? Australia is reviewing its timetable for buying 12 of the troubled F-35 Joint Strike Fighters between 2015 and 2017 after the Unites States announced a rethink of its own purchase schedule for the futuristic warplanes.
Australia is a funding partner in developing the JSF, which the U.S. Defense Department describes as the largest fighter aircraft program in history.
Australian Defense Minister Stephen Smith said Monday that Australia is only contractually obligated to take delivery of two of the warplanes. They will be based in the United States and be available from 2014 for training Australian pilots.
Smith says Australia is reconsidering its schedule of buying another 12 during the following three years.
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NEW YORK ? Oil prices are down on concerns that the U.S. economy could slow and investors' worries eased about supply disruptions in the Persian Gulf.
Benchmark crude fell by 34 cents to $99.22 per barrel in New York on Monday. Brent crude, which is used to price foreign oils that are imported by U.S. refineries, lost 28 cents at $111.18 per barrel in London.
The Commerce Department said Americans kept a tighter grip on their wallets in December. Consumer spending was flat, even though incomes rose by the most in nine months. The economy relies heavily on consumer spending, and analysts say the economic recovery could stall and energy demand may stay weak if spending doesn't pick up.
Meanwhile, Iran welcomed international weapons experts into the country in hopes of refuting claims that it is building a nuclear weapon. That eased concerns about possible military action in the region. Still, Europe plans to embargo Iranian oil this summer to pressure Iran about its nuclear program. If that happens, Iran says it could retaliate by blocking passage through the Persian Gulf, where tankers carry one-sixth of the world's oil exports.
The U.S. is ready to implement sanctions on Iran's central bank that will make it harder for Iran to sell oil.
Gasoline pump prices rose by a penny on Monday to $3.43 per gallon, according to AAA, Wright Express and Oil Price Information Service. A gallon of regular is 15.3 cents higher than it was a month ago and 33 cents higher than it was last year.
In other energy trading, heating oil was flat at $3.07 per gallon and gasoline futures fell 5 cents to $2.88 per gallon. Natural gas futures fell by 1 cent to $2.75 per 1,000 cubic feet.
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Davos is supposed to be the gathering ground for the global elite. I was reminded the first day, when I went to register for the forum. I entered a tent and submitted my passport to an elderly Swiss woman at the front desk and she could not find my name among the group of registered participants. Then she checked further and said I was a "media leader." I immediately said no, I'm not a leader. She insisted, however, noting that I went to the wrong tent; she is supposed to register representatives of the media, and media leaders are supposed to go to a different tent. I wanted to explain that my own father was a journalist, some of my best friends are journalists, I learn as much from talking to them as they learn from me, it's not a question of leading anybody, but I could tell she was getting impatient. So I went to the bigger tent next door to register as a "leader." I soon found out, however, that not all leaders are equal.
The "Summer Davos" is held in China every year, and it alternates between Dalian and Tianjin. I had been to the Dalian forum on a couple of occasions and it is indeed a smoothly run operation. All participants are flown in business class, and we are whisked from our five-star hotels to the conference site along wide boulevards with lanes blocked off just for the forum participants. In Beijing, I'd be upset at traffic jams caused by lanes blocked off for high-level government officials, but I confess it felt good to be on the other end of the hierarchical system. Of course I realized the whole thing was artificial and that the Cinderella-like ball would end at midnight (in my case), but I never did get a sense that I was a less-than-equal member of the "global elite" during the ball itself.
In Davos, it's a different story. Most academics stay in a three-star hotel. The most telltale sign that we are not so important is that there is no security at the door. Political leaders and CEOs stay at five-star hotels with security guards outside, and an airport like scanner at the entrance. Those without electronic World Economic Forum badges are refused entrance. I once forgot my badge and was refused entry for a dinner talk I had signed up for at one of the hotels. I tried to talk my way in, but the burly policeman waved me off and told his mate, in French, that I was annoying him. I switched to French and he seemed to lighten up a bit. Finally, he let me phone a WEF staff member who sorted out the problem.
Davos is a bigger deal, with more state leaders and CEOs than "regional" WEF meetings. The initial invitation letter noted that the forum includes political leaders from "G20 and other important countries." I felt bad for the not-so-important countries. Which ones did they have in mind, I wonder? Azerbaijian, perhaps? Turns out that my guess was wrong. My hotel room included gifts from Azerbaijian, which meant that they must have a delegation here.
The town itself is crawling with security forces. There are over 40 state leaders and they obviously need to be protected. But some countries seem to perfect the gangster look, with state leaders surrounded by seven-foot tall bodyguards with dark sunglasses (worn indoors), and one guesses it must be countries like Azerbaijian. After one session in an exclusive hotel, I was about to step into an elevator when a huge guy blocked my way. He told me, in broken English, it's the president, make way for him. I did not argue.
Davos is perhaps the only global forum where state leaders are not keynote speakers. This time, only Angela Merkel delivered a keynote address. Other leaders are put in rooms that vary in size, depending on perceptions of the country's power. The leader of Singapore was put in a small room for a half hour interview with Fareed Zakaria. The leader of Mexico was put in a huge room that was filled to capacity, but I guessed that the real draw was Bill Gates, who interviewed the president.
My guess proved to be correct, because the Mexican leader was followed by the Canadian Prime Minister, and the room emptied. The Canadian leader is a right-wing conservative and I'm not supposed to like him, but my nationalist feelings kicked in. I really felt horrible, and his uninspired speech did not lift my spirits. The next day, the (Toronto-based) Globe and Mail reported on his speech with the headline "Prime Minister Harper unveils grand plan to reshape Canada" and I was reminded of the infamous award-winning entry for the most boring headline contest, "Worthwhile Canadian Initiative." The article itself didn't mention the sparse crowd.
Still, at least I could take comfort from the fact that other countries seemed to be even lower down in the global pecking order. The president of Azerbaijian was put on a panel with three other not-so-important countries. I didn't go to that panel.
Of course, such feelings of superiority are not justified from a moral point of view, and last night Azerbaijian took its revenge. I dreamt I was lost in a tall building in Davos, and I had forgotten my WEF badge. A mammoth of a man from Azerbaijian blocked my way. I tried to explain I was a participant at Davos, but he ignored my pleas. He brought me to the edge of the building and was about to throw me over. I woke up, bathed in sweat.
?
Source: http://www.huffingtonpost.com/daniel-a-bell/davos-2012_b_1240089.html
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ROY, Utah ? The two teens had a detailed plot, blueprints of the school and security systems, but no explosives. They had hours of flight simulator training on a home computer and a plan to flee the country, but no plane.
Still, the police chief in this small Utah town said, the plot was real.
"It wasn't like they were hanging out playing video games," Roy Police Chief Gregory Whinham said Friday. "They put a lot of effort into it."
Dallin Morgan, 18, and a 16-year-old friend were arrested Wednesday at Roy High School, about 30 miles north of Salt Lake City, after a fellow student reported that she received ominous text messages from one of the suspects.
"If I tell you one day not to go to school, make damn sure you and your brother are not there," one message read, according to court records. "We ain't gonna crash it, we're just gonna kill and fly our way to a country that won't send us back to the U.S.," read another message.
While police don't have a motive, one text message noted they sought "revenge on the world."
The suspects say they were inspired by the deadly 1999 Columbine High School shootings in Littleton, Colo., and the younger suspect even visited the school last month to interview the principal about the shootings and security measures.
However, one suspect told authorities it was offensive to be compared to the Columbine shooters because "those killers only completed 1 percent of their plan," according to a probable cause statement.
The teens had so studied their own school's security system that they knew how to avoid being seen on the facility's surveillance cameras, authorities said.
Whinham said the "very smart kids" had spent at least hundreds of dollars on flight simulator programs, books and manuals, studying them in anticipation of carrying out their plan to bomb an assembly at the 1,500-student high school.
While authorities said the suspects believed they could pull it off, experts said, it would have been a long shot.
Royal Eccles, manager at the Ogden-Hinckley Airport, about a mile from the school, said it would have been nearly impossible for the students to steal a plane or get the knowledge to fly one using flight simulator programs.
"It's highly improbable," Eccles said. "That's how naive these kids are."
Whinham said authorities searched two homes and two cars and found no explosives, but added that police continue to search other locations. The chief said it appeared that "a key component of their plan was not developed."
"I wouldn't want to say that they don't have it or that they weren't ready for it," he said. "I'm just saying that we haven't found anything that says they were ready for it yet."
Whinham said it appeared the suspects, who have no criminal history, also had prepared alternate attack plans, but he declined to elaborate. He also declined to say whether any firearms were found during their searches.
"Most houses have firearms in them," he said. "This is the state of Utah."
While authorities have said they have not found any explosives, they charged Morgan on Friday with possession of a weapon of mass destruction.
The basis for the charge wasn't immediately clear, though one of the elements of that offense is conspiracy to use a weapon, not necessarily possessing one. Prosecutors say they are considering additional charges.
Morgan has been released on bond, pending a court hearing Wednesday. The 16-year-old, whom The Associated Press isn't naming because he's a minor, remained held pending further court hearings.
Whinham said he knew both suspects personally, given the small size of the suburban Utah town of roughly 36,000 people. He said he had met with both of the suspects' parents and they were "devastated."
The 16-year-old suspect's father declined comment Friday, and no one answered the door at Morgan's home.
The plot "was months in planning," said Whinham, who also noted Morgan told investigators the 16-year-old had previously made a pipe bomb using gun powder and rocket fuel.
In Colorado, Columbine Principal Frank DeAngelis confirmed Friday he met with the 16-year-old suspect on Dec. 12 after the teenager told him he was doing a story for his school newspaper on the shootings.
DeAngelis said he frequently gets requests from students doing research on the shootings, and the request from this one wasn't unusual.
"He asked the same questions I get from many callers and visitors asking about the shooting," DeAngelis said. He said the student wanted details about the shooting, the aftermath and the steps taken since then to protect the school.
Police said the student told them Roy school officials would not allow him to write the story.
DeAngelis said he was shocked when he got a call from Utah police on Wednesday asking if he had met with the youth. He said the interview raised no red flags but that he would do things differently with future requests.
"This was definitely a wake-up call. This is the first time this has happened," DeAngelis said.
Police credit the suspects' schoolmate with helping foil their plan, though Whinham said the school didn't have any assemblies set, and the suspects revealed no specific dates to pull off the attack.
Sophomore Bailey Gerhardt told The Salt Lake Tribune she received alarming text messages from one of the suspects and alerted school administrators.
"I get the feeling you know what I'm planning," read one of the messages, according to court records. "Explosives, airport, airplane."
___
Associated Press writer Steven K. Paulson in Denver contributed to this report.
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DAVOS, Switzerland (Reuters) ? U.S. Treasury Secretary Timothy Geithner pressed Europe on Friday to boost its bailout fund resources, citing the euro zone debt crisis and oil prices as the two main factors influencing the pace of the United States' economic upturn.
The U.S. economy is growing at an annual rate of around 2-3 percent, Geither told the World Economic Forum in Davos, adding that it still faces big challenges to repair damage wrought by the financial crisis.
Earlier on Friday, euro zone finance officials voiced optimism at the Forum that key building International Monetary Fund could help support Europe through its debt crisis if the euro zone boosts its bailout funds, or "firewall," he said.
"Our view is that the only way Europe is going to be successful in holding this together is for them to bring a stronger firewall and that is going to demand a bigger commitment," Geithner told the Forum.
"If Europe is able and willing to do that we believe the IMF is ready to play a constructive role," he added. "I think you'll see the IMF (be) very supportive in those efforts but not as a substitute for blocks to resolve the sovereign debt crisis (that) are gradually fitting into place.
The health of U.S. business was better than expected, Geithner said, dismissing the suggestion that tighter regulations were hampering growth.
"Profitability across the US economy is very high," he added. "What is holding the US economy back still is the aftershocks of the financial crisis and the fiscal pressure on governments."
Turning to Iran, he said Washington's drive to cut Iran's oil exports was getting excellent support from Europe and that there were positive signs from China too.
"Even over the last 6 months you're seeing a substantial intensification in (cutting) dependence on Iranian oil and my sense is also that China wants to be part of that effort because it is in China's interests not to see Iran undo the delicate balance in the Gulf," he added.
On his own future, Geithner reaffirmed that he would not expect to be asked to continue as Treasury chief if President Barack Obama wins re-election.
"Generally anybody who takes these jobs serves at the pleasure of the president," he said.
"When he asked me to stay when I thought it was the right time to leave, I agreed to stay and I agreed I would stay to the balance of this term. He accepted that aspiration of mine, and that's where it's going to come out, I think."
Geithner declined to say what he would do next: "That feels like a long way away."
(Reporting by Paul Carrel and Janet McBride; editing by Patrick Graham)
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ARKADELPHIA, Ark. ? Authorities in Arkansas were searching Sunday for a suspect wanted in a homicide and kidnapping case involving a distant relative of former Arkansas Gov. Mike Huckabee.
Police issued an arrest warrant for Donald Hux after investigators found the body of Sandy Carl Huckabee at his home in Arkadelphia, which is about 70 miles southwest of Little Rock.
Former Huckabee spokesman Jim Harris said Sandy Huckabee's father was the first cousin of former presidential hopeful Mike Huckabee's father.
Authorities said Hux abducted his ex-wife, Amy Huckabee, and their three children in Arkadelphia before he drove to El Dorado, which is about 80 miles away. He dropped the children off somewhere in southern Arkansas' Union County, which is where El Dorado is located, the local sheriff's office said in a statement. Union County Sheriff's Capt. Clark Burton told The Associated Press the children were not hurt.
Meanwhile, police in Arkadelphia learned about the situation and went to the Huckabee home to do a welfare check. They found Sandy Huckabee's body inside, but they had yet to find his wife, Amy Huckabee, as of Sunday evening.
Hux is wanted on capital murder, kidnapping, burglary and firearms charges.
He was last seen driving a tan 2005 Chevrolet extended cab truck with the license plate 487-MDZ.
No one answered the phone at one number listed for Donald Hux in El Dorado. Another number for Donald Hux there was disconnected.
Harris, the spokesman when Huckabee was governor, said the former Republican governor was traveling Sunday but had learned of the distant relative's death.
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ReutersA few East-West Shrine Game participants that could fit with the Bills.
An analysis of the Dolphins? choice to hire Joe Philbin as their head coach.
Patriots CB Devin McCourty is looking forward to facing off with Ravens RB Ray Rice, his teammate at Rutgers.
The Jets signed G Trevor Canfield to a futures contract.
The Ravens defense knows that they need to make Tom Brady uncomfortable on Sunday.
Some reaction to the Bengals? decision to hold training camp at Paul Brown Stadium.
The healthy return of G Eric Steinbach will give the Browns needed depth on the offensive line.
The Steelers may buck their tradition of promoting from within when it comes to hiring a new offensive coordinator.
Texans C Chris Myers and DE Antonio Smith are fired up for their first trip to the Pro Bowl.
Peter King of SI.com believes Peyton Manning?s status will have nothing to do with the Colts? search for a new coach.
The Jaguars signed four more assistant coaches for Mike Mularkey?s staff.
Titans CB Cortland Finnegan doesn?t think shuffling the front office will change much about the organization.
The Broncos will spend some time evaluating QB Adam Weber this offseason.
The New Yorker checks in on the phone tapping allegations hurled at the Chiefs last week.
Paul Gutierrez of CSNBayArea.com thinks the Dolphins making a coaching hire puts the pressure on the Raiders.
Ron Meeks is the leading candidate for the job as Chargers? defensive backs coach.
Cowboys LB Keith Brooking hopes that WR Dez Bryant doesn?t waste his talent.
Giants defensive backs credit group meetings for their improved play.
More questions about where the Eagles defense is going this offseason.
A trial date has been set for the man accused of shooting and killing Redskins S Sean Taylor.
A look at what Phil Emery might bring to the table as Bears general manager.
Does RB Kevin Smith have a future with the Lions?
Packers S Nick Collins will learn more about his future after a meeting with doctors in March.
USC T Ryan Kalil and Oklahoma State WR Justin Blackmon are both candidates for the Vikings in the first round.
The Falcons signed RB Dimitri Nance to a futures contract.
It isn?t guaranteed that the Panthers will opt for a defensive player in the first round of the draft.
Looking back at Gregg Williams? run as defensive coordinator of the Saints.
Five players the Buccaneers should be watching at the Senior Bowl.
The Cardinals lost painful games to the Ravens and Giants, but managed a split with the 49ers.
Said Rams executive vice president of football operations Kevin Demoff of the team?s plans to play games in London the next three years, ?And our fans are going to have conspiracy theories and be skeptics of our intentions. But hopefully throughout this process, our actions about wanting to be here will speak for us.?
49ers coach Jim Harbaugh didn?t get a chance to hold a practice in rainy conditions.
The Seahawks did well in sudden change situations this season.
Source: http://profootballtalk.nbcsports.com/2012/01/21/rex-says-he-may-tone-it-down/related/
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WELLINGTON (Reuters) ? New Zealand police broke through electronic locks and cut their way into a mansion safe room to arrest the alleged kingpin of an international Internet copyright theft case and seize millions of dollars worth of cars, artwork and other goods.
German national Kim Dotcom, also known as Kim Schmitz, was one of four men arrested on Friday in an investigation of the Megaupload.com website led by the U.S. Federal Bureau of Investigation.
The group was accused of engaging in a scheme that took more than $500 million away from copyright holders and generated over $175 million in proceeds from subscriptions and advertising.
A police official said on Saturday that dozens of officers, backed by helicopters, forced their way into the mansion, nestled in lush farmland, after Dotcom refused them entry.
"Despite our staff clearly identifying themselves, Mr Dotcom retreated into the house and activated a number of electronic-locking mechanisms," said Detective Inspector Grant Wormald from the Organised & Financial Crime Agency New Zealand.
Officers broke the locks and Dotcom barricaded himself into a safe room which officers had to cut their way into, he said.
"Once they gained entry into this room, they found Mr Dotcom near a firearm which had the appearance of a shortened shotgun," he said. "It was definitely not as simple as knocking at the front door."
PINK CADILLAC
Two firearms were seized and a 55-year-old New Zealand man had been charged with illegal possession of a pistol. Computers and documents were also retrieved and more than NZ$10 million ($8 million) was seized from financial institutions.
Television footage showed vehicles, including a pink Cadillac and a Rolls-Royce Phantom Drophead Coupe, being removed from the property north of Auckland, New Zealand's largest city.
The arrests were made as the debate over online piracy reaches fever pitch in Washington where Congress is trying to craft tougher legislation.
Lawmakers stopped anti-piracy legislation on Friday, postponing a critical vote in a victory for Internet companies that staged a mass online protest against the fast-moving bills.
The movie and music industries want Congress to crack down on Internet piracy and content theft, but major Internet companies like Google and Facebook have complained that current drafts of the legislation would lead to censorship.
"Our focus now is on completing all the documentation required by crown law ahead of the next court appearance on Monday," Wormald said of the Auckland arrests.
"The team of four FBI staff will also remain working with us for the next few days."
Kim, who turns 38 on Saturday, and the other men made a brief court appearance on Friday will appear again on Monday. They face extradition and a trial in the United States.
On Friday, in a show of support, hackers attacked and temporarily disabled a number of government and entertainment company websites, including the U.S. Justice Department's website.
U.S. Justice Department officials have said that the estimate of $500 million in economic harm to copyright holders cited in a U.S. indictment was at the low end and could be significantly more.
The allegations included copyright infringement as well as conspiracy to commit copyright infringement, conspiracy to commit money laundering and conspiracy to commit racketeering. Two of the offences carry a maximum penalty of 20 years.
The companies charged, Megaupload Ltd and Vestor Ltd, were both registered in Hong Kong and owned either in large part or solely by Dotcom.
Megaupload has boasted of having more than 150 million registered users and 50 million daily visitors, according to the indictment. At one point, it was estimated to be the 13th most frequently visited website on the Internet.
Users could upload material to the company's sites which then would create a link that could be distributed. The sites, which included video, music and pornography, did not provide search capabilities but rather relied on others to publish the links, the U.S. indictment said.
(Editing by Lincoln Feast and Ron Popeski)
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By Roberta RamptonPosted 2012/01/20 at 8:34 pm EST
WASHINGTON, Jan. 20, 2012 (Reuters) ? The Congress has the constitutional right to legislate permits for cross-border oil pipelines like TransCanada's Keystone XL, according to a new legal analysis released late on Friday.
The study by the nonpartisan Congressional Research Service could give a boost to Republicans drafting legislation to overturn a decision this week by President Barack Obama to put the $7 billion Alberta-to-Texas project on ice.
Historically, U.S. presidents have made executive decisions on pipelines that cross borders. But Congress had the power all along to weigh in on the permits, said the study, done by four legislative attorneys with the CRS.
"If Congress chose to assert its authority in the area of border-crossing facilities, this would likely be considered within its Constitutionally enumerated authority to regulate foreign commerce," the study said.
Republicans in Congress have elevated the Canadian pipeline and the construction jobs it would create as a top election-year issue, accusing Obama of caving to environmental groups. They pushed to include a deadline for a permit approval in a payroll tax cut bill that Obama signed into law in December.
But this week, Obama and the State Department said an environmental review of a portion of the proposed pipeline could not be rushed, closing the door on a quick start to the project.
REPORT "HELPS THE CONVERSATION"
The CRS report "greatly helps the conversation" among Senate and House Republicans strategizing about how to keep the project alive, said Ryan Bernstein, an energy advisor for Senator John Hoeven of North Dakota.
"I think this confirms what we've been saying along - Congress has the authority to approve the Keystone pipeline," said Bernstein, who is helping Hoeven draft legislation that would see Congress green-light the project.
Earlier on Friday, Republicans in the House of Representatives said they were considering using upcoming payroll tax cut or highway construction bills to force quick approval of the pipeline.
Representative Lee Terry, whose home state of Nebraska would host part of the pipeline, has drafted legislation to shift the Keystone decision-making process from the Obama administration to the independent Federal Energy Regulatory Commission, which regulates pipelines in the United States.
The House Energy and Commerce Committee will hold a hearing on Wednesday about Terry's bill and other Keystone measures.
(Editing by Philip Barbara)
Number of stories in archives: 2,855
Source: http://www.newsdaily.com/stories/tre80k043-us-usa-pipeline-legislation/
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NEW YORK ? Morgan Stanley posted a fourth-quarter loss of $275 million Thursday, its first since early 2009, as the investment bank booked a charge from settling a dispute over failed mortgage securities.
The loss, a reversal from its gain of $600 million a year ago, was far smaller than investors were expecting and the company's stock jumped 6 percent in early trading. Morgan Stanley's loss was equivalent to 15 cents per share, versus the 43 cents analysts were predicting, according to FactSet.
The loss stemmed from Morgan Stanley's settlement last month with bond insurer MBIA, an agreement that slashed earnings by 59 cents per share. MBIA had accused Morgan Stanley of being misleading about the quality of commercial mortgage-backed securities it wanted insured.
Morgan Stanley and other banks accused the insurer of restructuring itself to avoid paying claims the banks made. While the settlement took a deep hit on quarterly results, Morgan Stanley portrayed it as a step in cleaning up its balance sheet.
Glenn Schorr, an analyst at Nomura Equity Research, said that Morgan Stanley's earnings were better than its peers, excluding the MBIA-related loss, and its stock trading fell less than at other banks. Overall, Schorr said, Morgan Stanley is "making progress cleaning up legacy issues" but "is still a work in progress."
Schorr also emphasized how the bank last year cut out some expensive payments to its largest shareholder, Japanese bank Mitsubishi UFJ Financial Group, by persuading it to convert its holdings to common stock from preferred stock.
Like its peers, Morgan Stanley has been trimming expenses and cutting jobs as the economy continues to struggle. Even so, it set aside more money for paying a smaller number of workers. The average compensation it paid for the year was $265,000, up from about $255,000 the year before.
Morgan Stanley is also figuring out how to redefine itself as new government regulations crimp former sources of revenue, including some complicated investment vehicles and trading for its own profit.
Quarterly revenue of $5.7 billion was down from $7.7 billion a year ago. The bank's institutional securities unit swung to a loss. It also posted a 68 percent decline in revenue, as nervous clients held off on underwriting new deals or pursuing mergers. The institutional securities unit, the bank's largest, helps clients with investment banking services like packaging securities and trading currencies.
Though investment banking is always volatile, the risks are more pronounced at Morgan Stanley. Unlike some of its rivals, like JPMorgan Chase & Co. and Bank of America Corp., Morgan Stanley doesn't have a large consumer deposit base or much plain-vanilla lending to rely on when its investment bank stumbles.
CEO James Gorman said in a statement that Morgan Stanley has been "addressing a number of outstanding strategic and legacy issues" for the past year.
Gorman, who became CEO in 2010, has been slimming down the bank, selling off units like a mortgage servicing division and an asset management business. He's been emphasizing divisions like wealth management, which provide smaller returns than some investment banking operations used to but also carry a lot less risk because they're based on fees rather than markets.
Despite those efforts, Morgan Stanley's wealth management unit struggled in the quarter. Revenue fell 3 percent and profit fell 20 percent for the unit, which offers financial planning for wealthy individuals and small to medium-sized businesses. Asset management, which manages investment portfolios, also reported lower revenue and profits, thanks in part to souring investments in real estate.
Morgan Stanley's stock jumped 6 percent to $18.32.
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Public release date: 18-Jan-2012
Share ] Contact: James Riordon
riordon@aps.org
301-209-3238
American Physical Society
The American Physical Society's 2012 March meeting will focus on some of the most dynamic and cutting-edge research areas in physics. The topics on tap include high temperature superconductivity, biophysics, and advanced materials, as well as talks and sessions dedicated to social issues, medical technology, energy, and national security. The meeting takes place February 27March 2 at the Boston Convention Center in Boston, Mass.
Registration is free for journalists. Contact James Riordon (riordon@aps.org, 301-209-3238) to register as press. Meeting details, including housing information and the complete meeting schedule, are available at: http://aps.org/meetings/march/index.cfm.
Here is a brief list of some of the topics that will be highlighted in subsequent press releases and press conferences at the 2012 APS March meeting.
Soft robots: mobile, agile, and fast
Session P52 -- http://meetings.aps.org/Meeting/MAR12/Event/163850
"Nanostethoscope" probes living organisms using atomic force microscopy
Session H1 -- http://meetings.aps.org/Meeting/MAR12/Event/160923
Microwave imaging through walls for urban reconnaissance
Session D20 -- http://meetings.aps.org/Meeting/MAR12/Event/160563
Making e-readers and other electronics out of paper
Session B42 -- http://meeting.aps.org/Meeting/MAR12/Event/159863
Tracking word and language evolution with Google
Session J54 -- http://meetings.aps.org/Meeting/MAR12/Event/162218
Imaging method for measuring Botox efficacy
Session A1 -- http://meetings.aps.org/Meeting/MAR12/Event/158646
The physics of ponytails
Session H52 -- http://meeting.aps.org/Meeting/MAR12/Event/161532
Electronic devices made from spider silk
Session W49 -- http://meeting.aps.org/Meeting/MAR12/Event/166712
The kitchen as a lab, featuring chef superstars Ferran Adria and Jose Andres
Session G1 -- http://meetings.aps.org/Meeting/MAR12/Event/160915
Carbon nanotube scaffolding for spinal cord repair
Session W39 -- http://meetings.aps.org/Meeting/MAR12/Event/165330
Physics of color reflective displays: revolution in display technology
Session X20 -- http://meeting.aps.org/Meeting/MAR12/sessionindex2/?SessionEventID=167000
Textured nanostructures for anti-icing on airplanes and other surfaces
Session B46 -- http://meetings.aps.org/Meeting/MAR12/Event/159902
Fukushima: impact and lessons
Session W20 -- http://meetings.aps.org/Meeting/MAR12/SessionIndex2/?SessionEventID=169119
Improving the safety of Soviet-era nuclear reactors
Session L37 -- http://meetings.aps.org/Meeting/MAR12/Event/162997
Cheating bacteria curb evolution of antibiotic resistance
Session Q42 -- http://meeting.aps.org/Meeting/MAR12/Event/164388
Designer materials and mapping out the materials genome
Session A7 -- http://meeting.aps.org/Meeting/MAR12/Event/158717
Fractal behavior marks cancer cells
Session D42 -- http://meetings.aps.org/Meeting/MAR12/Event/160830
K-12 science education: closing the gap with the leading nations
Session J2 -- http://meetings.aps.org/Meeting/MAR12/SessionIndex2/?SessionEventID=161585
Algae-herding for the biotech industry
Session Y48 -- http://meetings.aps.org/Meeting/MAR12/Event/166689
Exploring a fern's natural, ultrafast catapult system
Session Z40 -- http://meeting.aps.org/Meeting/MAR12/Event/168274
###
ABOUT APS
The American Physical Society (www.aps.org) is a non-profit membership organization working to advance and diffuse the knowledge of physics through its outstanding research journals, scientific meetings, and education, outreach, advocacy and international activities. APS represents 48,000 members, including physicists in academia, national laboratories and industry in the United States and throughout the world. Society offices are located in College Park, MD (Headquarters), Ridge, NY, and Washington, DC.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 18-Jan-2012 Share ] Contact: James Riordon
riordon@aps.org
301-209-3238
American Physical Society
The American Physical Society's 2012 March meeting will focus on some of the most dynamic and cutting-edge research areas in physics. The topics on tap include high temperature superconductivity, biophysics, and advanced materials, as well as talks and sessions dedicated to social issues, medical technology, energy, and national security. The meeting takes place February 27March 2 at the Boston Convention Center in Boston, Mass.
Registration is free for journalists. Contact James Riordon (riordon@aps.org, 301-209-3238) to register as press. Meeting details, including housing information and the complete meeting schedule, are available at: http://aps.org/meetings/march/index.cfm.
Here is a brief list of some of the topics that will be highlighted in subsequent press releases and press conferences at the 2012 APS March meeting.
Soft robots: mobile, agile, and fast
Session P52 -- http://meetings.aps.org/Meeting/MAR12/Event/163850
"Nanostethoscope" probes living organisms using atomic force microscopy
Session H1 -- http://meetings.aps.org/Meeting/MAR12/Event/160923
Microwave imaging through walls for urban reconnaissance
Session D20 -- http://meetings.aps.org/Meeting/MAR12/Event/160563
Making e-readers and other electronics out of paper
Session B42 -- http://meeting.aps.org/Meeting/MAR12/Event/159863
Tracking word and language evolution with Google
Session J54 -- http://meetings.aps.org/Meeting/MAR12/Event/162218
Imaging method for measuring Botox efficacy
Session A1 -- http://meetings.aps.org/Meeting/MAR12/Event/158646
The physics of ponytails
Session H52 -- http://meeting.aps.org/Meeting/MAR12/Event/161532
Electronic devices made from spider silk
Session W49 -- http://meeting.aps.org/Meeting/MAR12/Event/166712
The kitchen as a lab, featuring chef superstars Ferran Adria and Jose Andres
Session G1 -- http://meetings.aps.org/Meeting/MAR12/Event/160915
Carbon nanotube scaffolding for spinal cord repair
Session W39 -- http://meetings.aps.org/Meeting/MAR12/Event/165330
Physics of color reflective displays: revolution in display technology
Session X20 -- http://meeting.aps.org/Meeting/MAR12/sessionindex2/?SessionEventID=167000
Textured nanostructures for anti-icing on airplanes and other surfaces
Session B46 -- http://meetings.aps.org/Meeting/MAR12/Event/159902
Fukushima: impact and lessons
Session W20 -- http://meetings.aps.org/Meeting/MAR12/SessionIndex2/?SessionEventID=169119
Improving the safety of Soviet-era nuclear reactors
Session L37 -- http://meetings.aps.org/Meeting/MAR12/Event/162997
Cheating bacteria curb evolution of antibiotic resistance
Session Q42 -- http://meeting.aps.org/Meeting/MAR12/Event/164388
Designer materials and mapping out the materials genome
Session A7 -- http://meeting.aps.org/Meeting/MAR12/Event/158717
Fractal behavior marks cancer cells
Session D42 -- http://meetings.aps.org/Meeting/MAR12/Event/160830
K-12 science education: closing the gap with the leading nations
Session J2 -- http://meetings.aps.org/Meeting/MAR12/SessionIndex2/?SessionEventID=161585
Algae-herding for the biotech industry
Session Y48 -- http://meetings.aps.org/Meeting/MAR12/Event/166689
Exploring a fern's natural, ultrafast catapult system
Session Z40 -- http://meeting.aps.org/Meeting/MAR12/Event/168274
###
ABOUT APS
The American Physical Society (www.aps.org) is a non-profit membership organization working to advance and diffuse the knowledge of physics through its outstanding research journals, scientific meetings, and education, outreach, advocacy and international activities. APS represents 48,000 members, including physicists in academia, national laboratories and industry in the United States and throughout the world. Society offices are located in College Park, MD (Headquarters), Ridge, NY, and Washington, DC.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-01/aps-std_1011812.php
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Already available in Fujitsu?s home market of Japan, the outfit was showing off its waterproof Windows Phone 7.5 smartphone at the Consumer Electronics Show in an effort to gauge enthusiasm and interest as Fujitsu is hoping to crack the U.S. market. The phone has a waterproof coating, which Fujitsu had demonstrated by dunking the phone in a tub of water.
While the 13.2-megapixel sensor of Fujitsu?s Mango-powered Windows Phone device was advanced when it was announced, HTC?s recent introduction of the Titan II for AT&T?s 4G LTE network outdoes Fujitsu with a 16-megapixel camera. The camera on Fujitsu?s model can record video in 720p, which may be more of a limitation with Windows Phone supporting only single-core CPUs as 1080p video recording is more typically seen with dual-core CPUs.
Fujitsu says that it hopes to enter the U.S. market within the next several years. As part of its plans, the company candidly told me that it will focus both on Windows Phone 7 and Android smartphones in North America.
Source: http://feedproxy.google.com/~r/Gottabemobile/~3/LVpXMrgprws/
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Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/gr59IakBnGA/story01.htm
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Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/zuv82h_J_iw/story01.htm
LONDON (AP) ? It's spry versus spy as frothy silent movie "The Artist" and moody thriller "Tinker Tailor Soldier Spy" lead the race for the British Academy Film Awards, Britain's equivalent of the Oscars.
"The Artist" received 12 nominations and "Tinker Tailor" 11, with each film up for best picture and director, and best actor nominations for leading men Jean Dujardin and Gary Oldman.
The other best-film nominees, announced at a ceremony Tuesday by actors Daniel Radcliffe and Holliday Grainger, were "The Descendants," ''Drive" and "The Help."
In a diverse field not dominated by any single film, there are also multiple nominations for "Hugo," ''My Week With Marilyn," ''The Iron Lady" and "The Help."
The nominations are another feather in the cap of "The Artist," a black-and-white French film about a silent screen star's fall with the rise of talkies that has become an unlikely hit. On Sunday it won three Golden Globes, including best musical or comedy film.
Director Michael Hazanavicius said Tuesday he and his crew had been "a bit mad to make a black-and-white silent film in 2011."
"We certainly hoped to find an audience, but the support we have received from so many people in so many different countries was unexpected, overwhelming and quite wonderful," he said.
The shortlist gives a boost to "Tinker Tailor," an atmospheric adaptation of John le Carre's espionage classic that has received rave reviews but has so far been snubbed during the U.S. awards season.
"Tinker Tailor" producer Tim Bevan said the film was a "particularly British cultural phenomenon. It's great that it's being recognized at the BAFTAs but that it hasn't at the Golden Globes is not surprising."
"'The Artist' seems to be the film with the momentum, and rightly so," he said. "It's been an OK year but not a brilliant year for movies, and 'The Artist' defines what cinema should be. It's brave, different, it's got a great shot."
The best actor contest pits Oldman and Dujardin against Brad Pitt for "Moneyball," George Clooney for "The Descendants" and Michael Fassbender for "Shame."
The best actress category includes two performers playing real-life icons ? Michelle Williams as Marilyn Monroe in "My Week With Marilyn" and Meryl Streep as former Prime Minister Margaret Thatcher in "The Iron Lady."
Streep, who has been widely praised for her performance, said the nomination was "thrilling news ... Not just for me, but for the film of which I am very proud, and for the hundreds of people who worked on it! Thanks, from a (New) Jersey girl."
The other nominees are Berenice Bejo for "The Artist," Tilda Swinton for "We Need to Talk About Kevin" and Viola Davis for "The Help."
The prizes will be awarded at a ceremony at London's Royal Opera House on Feb. 12. They are considered an important indicator of prospects at the Academy Awards in Los Angeles two weeks later.
In recent years, the awards, known as BAFTAs, have helped small British films gain momentum for Hollywood success.
In 2010, Danny Boyle's "Slumdog Millionaire" won seven BAFTAs, including best film; it went on to take eight Oscars. Last year "The King's Speech" won seven BAFTAs and four Oscars, including best picture.
"My Week With Marilyn," the story of the movie legend's time shooting an ill-starred comedy in England, received six BAFTA nominations, including a supporting-actor nod for Kenneth Branagh, who plays Laurence Olivier.
He is up against Christopher Plummer for "Beginners," Jim Broadbent for "The Iron Lady," Jonah Hill for "Moneyball" and Philip Seymour Hoffman for "The Ides of March."
The supporting actress category features Carey Mulligan for "Drive," Jessica Chastain for "The Help," Judi Dench for "My Week With Marilyn," Melissa McCarthy for "Bridesmaids" and Octavia Spencer for "The Help."
The multinational best-director contest pits Hazanavicius against Denmark's Nicolas Winding Refn, for the turbocharged "Drive," Sweden's Tomas Alfredson for "Tinker Tailor," Britain's Lynne Ramsay for "We Need to Talk About Kevin" and Martin Scorsese of the United States for "Hugo."
The best British film category contains "My Week With Marilyn," racing documentary "Senna," sex-addiction drama "Shame," family tragedy "We Need to Talk About Kevin" and "Tinker Tailor Soldier Spy."
Steven Spielberg's equine adventure "War Horse" was overlooked in the major categories but gained five nominations, including cinematography, visual effects and music.
___
On the Net: http://www.bafta.org
Jill Lawless can be reached at: http://twitter.com/JillLawless
(This version CORRECTS Corrects spelling of Nicolas Winding Refn in 20th paragraph, style for black-and-white in fifth paragraph.)
BRUSSELS (Reuters) ? U.S. rating agency Standard & Poor's cut its credit rating of the euro zone's EFSF rescue fund on Monday, and Greece was under pressure to break a deadlock in debt swap talks if it is to avoid an unruly default.
French Finance Minister Francois Baroin said there was no need to shore up the European Financial Stability Facility after S&P downgraded it by one notch to AA+ from triple-A, echoing the view of Germany, the only major euro zone member to retain a top-notch credit rating.
S&P said in a statement the decision was all but inevitable following identical cuts three days earlier to the creditworthiness of France and Austria, two of the EFSF's guarantors.
"We consider that credit enhancements that would offset what we view as the now-reduced creditworthiness of the EFSF's guarantors and securities backing the EFSF's issues are currently not in place," the agency said in a statement.
"We have therefore lowered to AA+ the issuer credit rating of the EFSF, as well as the issue ratings on its long-term debt securities."
Financial markets, which had fallen after the mass downgrades of euro zone members on Friday, showed little reaction to the latest blow -- which had been expected -- and Japan, a major buyer of EFSF bonds, said they remained an "attractive" investment.
A growing number of experts, including a Standard & Poor's official, warned that a Greek default was on the cards, after Greece's talks with creditors broke down on Friday.
Greece was under growing pressure to secure a last-ditch agreement with its private creditors to accept voluntary losses on their holdings of Greek bonds.
Athens risks going bankrupt when 14.5 billion euros of bond redemptions fall due in late March. Without a private sector bond swap involving a voluntary writedown, a 130 billion euro second international bailout for Greece could fall apart.
The talks with creditor banks broke down because of different views on what interest rate is acceptable, the head of the group leading private sector talks said.
Charles Dallara, managing director of the Institute of International Financial, said the banks were "very surprised" at the stance taken by some officials representing both governments and multilateral institutions, without naming them.
The EFSF was set up by the 17 governments that share the European single currency in May 2010 and has so far been used to provide emergency loans to Ireland and Portugal. It is also expected to contribute to a second bailout of Greece.
The fund has an effective lending capacity of 440 billion euros, which depends on guarantees, mainly from the euro zone's AAA countries, only four of which now remain: Germany, Luxembourg, Finland and the Netherlands.
LENDING CAPACITY UNAFFECTED
In a statement, the EFSF said the downgrade would not affect its lending capacity, and emphasized that its short-term rating remained at S&P's top level.
"The downgrade to 'AA+' by only one credit agency will not reduce EFSF's lending capacity of 440 billion euros," said the fund's chief executive, Klaus Regling.
"EFSF has sufficient means to fulfill its commitments under current and potential future adjustment programs until the ESM becomes operational in July 2012," he added.
The ESM -- the European Stability Mechanism -- is a permanent rescue fund that is expected to have an effective capacity of 500 billion euros, based on paid-in capital of 80 billion euros and callable capital of 620 billion euros.
French Finance Minister Francois Baroin said there was no need to shore up the EFSF despite the S&P rating downgrade.
"The EFSF has kept intact its ability to lend, with enough means and guarantees to fulfill the full range of its present and future commitments," he said in a statement. "There is therefore no need to act on the EFSF at the moment."
German Chancellor Angela Merkel's spokesman, Steffen Seibert told reporters: "The government has no reason to believe that the volume of guarantees that the EFSF has now should not be sufficient to fulfill its current obligations.
"We should not forget that it has been decided to significantly move forward the ESM and to have it in place in mid-2012, one year earlier than planned."
There was also support from Japan, with Finance Minister Jun Azumi saying Tokyo's trust in EFSF bonds, in which it has so far invested 21 billion euros, had not been shaken.
"Japan has bought them by certain amounts and our stance will not immediately change just because of the downgrade," Azumi told reporters after a cabinet meeting.
The euro hovered just above a 17-month trough against the dollar early in Asia on Tuesday, but reaction to the S&P downgrade was muted. Trading overnight was subdued as U.S. markets were shut for the Martin Luther King holiday.
The head of Austria's debt office told Reuters the loss of Vienna's AAA status had also been priced into the market already, and Austria was able to sell treasury bills on Monday at rates very close to zero.
French President Nicolas Sarkozy brushed off the historic loss of Paris' top credit rating for the first time since 1975, a blow to his campaign for re-election in May, saying France's policy would not be dictated by rating agencies.
Contrasting S&P's move with a statement by rival watchdog Moody's, which still has France on an Aaa rating, he said: "My deep belief is that it changes nothing. We must reduce the deficit, we must reduce our spending and we must improve the competitiveness of our economy to return to a path of growth."
LOSERS TO PAY?
Italian Prime Minister Mario Monti, whose debt-laden country was downgraded by two notches along with Spain, called last week during a visit to Berlin for the EFSF to be increased to ward off attacks on his country's bonds.
But a senior politician in Merkel's conservative CDU party, Michael Meister, said it was the downgraded countries that should increase their guarantees for the fund.
"Germany was not downgraded so our contribution should not be changed. Countries that were affected must contribute more to the guarantees," Meister told Reuters.
Sources familiar with Greece's talks with its private creditors said EU paymaster Germany was pressing for new bonds to be given to banks in the planned swap to carry a low coupon of less than four percent that would increase the banks' effective losses to 75 percent.
The IMF was also weighing on the talks by warning that the Greek economy and the euro zone's economic outlook have worsened since the bailout package was agreed in October, raising Athens' funding needs to make its debt sustainable by 2020, they said.
Greece put a brave face on the standoff. "There is a little pause in these discussions," Greek Prime Minister Lucas Papademos told CNBC television. "But I am confident they will continue and we will reach an agreement that is mutually acceptable in time."
(Additional reporting by Lefteris Papadimos in Athens, Steve Slater and Richard Hubbard in London, Jan Strupczewski in Brussels and Fiona Ortiz in Madrid; Writing by Paul Taylor; Editing by Tim Pearce and Alex Richardson)
Public release date: 15-Jan-2012 Share ] Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-534-2208
Brigham and Women's Hospital
BOSTON, MA -- From tracking activities within bacteria to creating images of molecules that make up human hair, several experiments have already demonstrated the unique abilities of the revolutionary imaging technique called multi-isotope imaging mass spectometry, or MIMS, developed by researchers at Brigham and Women's Hospital (BWH). MIMS can produce high-resolution, quantitative three-dimensional images of stable isotope tags within subcellular compartments in tissue sections or cells.
With its use of stable isotopes as tracers, MIMS has opened the door for biomedical researchers to answer various biological questions, as two new studies have demonstrated. These studies looked at the use of MIMS in tracking cell division in intestinal stem cells, lipid turnover in Drosophila flies, protein turnover in ear cells, and opened the way to human application by detecting the formation of new white blood cells. Both studies will be published in Nature online on January 15, 2012 and in print on January 26, 2012.
In the first study, researchers used MIMS to test the much debated "immortal strand hypothesis" which claims that as stem cells divide, the older template DNA remains together in a stem cell, as the newer DNA is passed to cells that differentiate forming the digestive lining of the small intestine.
By tagging DNA with stable isotope tracers, researchers tracked DNA replication as cells divided. They found that in any situation DNA segregation was random, thereby disproving the immortal strand hypothesis.
The research opened another door by studying lipid metabolism within single lipid droplets of the fat body and of the central nervous system of Drosophila larvae. The researchers were also able to translate their work to humans. In a pilot study, they used MIMS to successfully track the formation of new white blood cells after administering isotope tracers in a healthy human volunteer.
The second study demonstrated that protein turnover in stereocilia in the inner ear is extremely slow contrary to the prevalent belief in the field. Stereocilia are hair-like projections found in cells of the inner ear that are responsible for hearing and maintaining balance. Using MIMS, researchers saw that protein turnover was very slow throughout the stereocilia, except the tip at the location of the mechanoelectrical transduction apparatus.
MIMS was created by developing several toolsan ion microscope/secondary-ion mass spectrometer, labeling with stable isotopes, and quantitative image-analysis software. Unlike other imaging technologies, MIMS does not require staining or the use of radioactive labeling. MIMS enables researchers to conduct experiments with safe, non-toxic stable isotopes, which are naturally occurring components of all living matter.
###
Claude Lechene, MD, professor in the Division of Genetics, Department of Medicine and director of the National Resource for Imaging Mass Spectrometry (National Institutes of Health), was the senior study author for both studies.
The first study was a collaboration among BWH researchers and Alex Gould, PhD, and Andrew Bailey, PhD from the Medical Research Council National Institute for Medical Research (UK). BWH researchers a part of the first study are lead study author Matthew Steinhauser, MD, Division of Cardiovascular Medicine, Department of Medicine; Samuel Senyo, PhD, Division of Cardiovascular Medicine, Department of Medicine; Christelle Guillermier, PhD, Division of Genetics, Department of Medicine; Todd Perlstein, MD, Division of Cardiovascular Medicine, Department of Medicine; and Richard Lee, MD, Division of Cardiovascular Medicine, Department of Medicine.
The second study was a collaboration among BWH researchers and researchers from the following institutions: Duan-Sun Zhang, PhD (lead study author) and Valeria Piazza, PhD in the laboratory of David Corey, PhD (HHMI investigator), Department of Neurobiology, Harvard Medical School. Other researchers that contributed to the study include Benjamin Perrin, PhD and James Ervasti, PhD both from the Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota and Agnieszka Rzadzinska, MD, and Haydn Prosser, PhD, of the Wellcome Trust Sanger Institute (UK). BWH researchers a part of the second study are Joseph Collin Poczatek, technical research assistant and Mei Wang, senior research assistant both in the Division of Genetics, Department of Medicine.
Research for the first study was supported by the National Institutes of Health, Ellison Medical Foundation, Human Frontier Science Program, American Heart Association, Future Leaders of Cardiovascular Medicine, Medical Research Council, Harvard Stem Cell Institute, and Cambridge Isotope Laboratories.
Research for the second study was supported by the National Institutes of Health/National Institute of Biomedical Imaging and Bioengineering, National Science Foundation Division of Integrative Biology and Neuroscience, and the Wellcome Trust.
Brigham and Women's Hospital (BWH) is a 793-bed nonprofit teaching affiliate of Harvard Medical School and a founding member of Partners HealthCare, an integrated health care delivery network. BWH is the home of the Carl J. and Ruth Shapiro Cardiovascular Center, the most advanced center of its kind. BWH is committed to excellence in patient care with expertise in virtually every specialty of medicine and surgery. The BWH medical preeminence dates back to 1832, and today that rich history in clinical care is coupled with its national leadership in quality improvement and patient safety initiatives and its dedication to educating and training the next generation of health care professionals. Through investigation and discovery conducted at its Biomedical Research Institute (BRI), http://www.brighamandwomens.org/research, BWH is an international leader in basic, clinical and translational research on human diseases, involving more than 900 physician-investigators and renowned biomedical scientists and faculty supported by more than $537 M in funding. BWH is also home to major landmark epidemiologic population studies, including the Nurses' and Physicians' Health Studies and the Women's Health Initiative. For more information about BWH, please visit http://www.brighamandwomens.org.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 15-Jan-2012 Share ] Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-534-2208
Brigham and Women's Hospital
BOSTON, MA -- From tracking activities within bacteria to creating images of molecules that make up human hair, several experiments have already demonstrated the unique abilities of the revolutionary imaging technique called multi-isotope imaging mass spectometry, or MIMS, developed by researchers at Brigham and Women's Hospital (BWH). MIMS can produce high-resolution, quantitative three-dimensional images of stable isotope tags within subcellular compartments in tissue sections or cells.
With its use of stable isotopes as tracers, MIMS has opened the door for biomedical researchers to answer various biological questions, as two new studies have demonstrated. These studies looked at the use of MIMS in tracking cell division in intestinal stem cells, lipid turnover in Drosophila flies, protein turnover in ear cells, and opened the way to human application by detecting the formation of new white blood cells. Both studies will be published in Nature online on January 15, 2012 and in print on January 26, 2012.
In the first study, researchers used MIMS to test the much debated "immortal strand hypothesis" which claims that as stem cells divide, the older template DNA remains together in a stem cell, as the newer DNA is passed to cells that differentiate forming the digestive lining of the small intestine.
By tagging DNA with stable isotope tracers, researchers tracked DNA replication as cells divided. They found that in any situation DNA segregation was random, thereby disproving the immortal strand hypothesis.
The research opened another door by studying lipid metabolism within single lipid droplets of the fat body and of the central nervous system of Drosophila larvae. The researchers were also able to translate their work to humans. In a pilot study, they used MIMS to successfully track the formation of new white blood cells after administering isotope tracers in a healthy human volunteer.
The second study demonstrated that protein turnover in stereocilia in the inner ear is extremely slow contrary to the prevalent belief in the field. Stereocilia are hair-like projections found in cells of the inner ear that are responsible for hearing and maintaining balance. Using MIMS, researchers saw that protein turnover was very slow throughout the stereocilia, except the tip at the location of the mechanoelectrical transduction apparatus.
MIMS was created by developing several toolsan ion microscope/secondary-ion mass spectrometer, labeling with stable isotopes, and quantitative image-analysis software. Unlike other imaging technologies, MIMS does not require staining or the use of radioactive labeling. MIMS enables researchers to conduct experiments with safe, non-toxic stable isotopes, which are naturally occurring components of all living matter.
###
Claude Lechene, MD, professor in the Division of Genetics, Department of Medicine and director of the National Resource for Imaging Mass Spectrometry (National Institutes of Health), was the senior study author for both studies.
The first study was a collaboration among BWH researchers and Alex Gould, PhD, and Andrew Bailey, PhD from the Medical Research Council National Institute for Medical Research (UK). BWH researchers a part of the first study are lead study author Matthew Steinhauser, MD, Division of Cardiovascular Medicine, Department of Medicine; Samuel Senyo, PhD, Division of Cardiovascular Medicine, Department of Medicine; Christelle Guillermier, PhD, Division of Genetics, Department of Medicine; Todd Perlstein, MD, Division of Cardiovascular Medicine, Department of Medicine; and Richard Lee, MD, Division of Cardiovascular Medicine, Department of Medicine.
The second study was a collaboration among BWH researchers and researchers from the following institutions: Duan-Sun Zhang, PhD (lead study author) and Valeria Piazza, PhD in the laboratory of David Corey, PhD (HHMI investigator), Department of Neurobiology, Harvard Medical School. Other researchers that contributed to the study include Benjamin Perrin, PhD and James Ervasti, PhD both from the Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota and Agnieszka Rzadzinska, MD, and Haydn Prosser, PhD, of the Wellcome Trust Sanger Institute (UK). BWH researchers a part of the second study are Joseph Collin Poczatek, technical research assistant and Mei Wang, senior research assistant both in the Division of Genetics, Department of Medicine.
Research for the first study was supported by the National Institutes of Health, Ellison Medical Foundation, Human Frontier Science Program, American Heart Association, Future Leaders of Cardiovascular Medicine, Medical Research Council, Harvard Stem Cell Institute, and Cambridge Isotope Laboratories.
Research for the second study was supported by the National Institutes of Health/National Institute of Biomedical Imaging and Bioengineering, National Science Foundation Division of Integrative Biology and Neuroscience, and the Wellcome Trust.
Brigham and Women's Hospital (BWH) is a 793-bed nonprofit teaching affiliate of Harvard Medical School and a founding member of Partners HealthCare, an integrated health care delivery network. BWH is the home of the Carl J. and Ruth Shapiro Cardiovascular Center, the most advanced center of its kind. BWH is committed to excellence in patient care with expertise in virtually every specialty of medicine and surgery. The BWH medical preeminence dates back to 1832, and today that rich history in clinical care is coupled with its national leadership in quality improvement and patient safety initiatives and its dedication to educating and training the next generation of health care professionals. Through investigation and discovery conducted at its Biomedical Research Institute (BRI), http://www.brighamandwomens.org/research, BWH is an international leader in basic, clinical and translational research on human diseases, involving more than 900 physician-investigators and renowned biomedical scientists and faculty supported by more than $537 M in funding. BWH is also home to major landmark epidemiologic population studies, including the Nurses' and Physicians' Health Studies and the Women's Health Initiative. For more information about BWH, please visit http://www.brighamandwomens.org.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-01/bawh-qia011312.php
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